Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.
Identifieur interne : 001124 ( Main/Exploration ); précédent : 001123; suivant : 001125Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.
Auteurs : Dieudonné Makaba Mvumbi [Oman] ; Raphael Boreux ; Rosalie Sacheli ; Mvumbi Lelo ; Bobanga Lengu ; Situakibanza Nani-Tuma ; Pierrette Melin ; Kayembe Ntumba ; Kalala Lunganza ; Patrick Demol ; Marie-Pierre HayetteSource :
- Malaria journal [ 1475-2875 ] ; 2013.
Descripteurs français
- KwdFr :
- ADN des protozoaires (), ADN des protozoaires (génétique), Analyse de séquence d'ADN, Antipaludiques (usage thérapeutique), Chloroquine (usage thérapeutique), Enfant d'âge préscolaire, Femelle, Fréquence d'allèle, Haplotypes, Humains, Mâle, Nourrisson, Nouveau-né, Paludisme à Plasmodium falciparum (parasitologie), Paludisme à Plasmodium falciparum (épidémiologie), Plasmodium falciparum (génétique), Plasmodium falciparum (isolement et purification), Protéines de protozoaire (génétique), Protéines de transport membranaire (génétique), Protéines mutantes (génétique), Réaction de polymérisation en chaine en temps réel, République démocratique du Congo (épidémiologie), Résistance aux substances.
- MESH :
- génétique : ADN des protozoaires, Plasmodium falciparum, Protéines de protozoaire, Protéines de transport membranaire, Protéines mutantes.
- isolement et purification : Plasmodium falciparum.
- parasitologie : Paludisme à Plasmodium falciparum.
- usage thérapeutique : Antipaludiques, Chloroquine.
- épidémiologie : Paludisme à Plasmodium falciparum, République démocratique du Congo.
- ADN des protozoaires, Analyse de séquence d'ADN, Enfant d'âge préscolaire, Femelle, Fréquence d'allèle, Haplotypes, Humains, Mâle, Nourrisson, Nouveau-né, Réaction de polymérisation en chaine en temps réel, Résistance aux substances.
English descriptors
- KwdEn :
- Antimalarials (therapeutic use), Child, Preschool, Chloroquine (therapeutic use), DNA, Protozoan (chemistry), DNA, Protozoan (genetics), Democratic Republic of the Congo (epidemiology), Drug Resistance, Female, Gene Frequency, Haplotypes, Humans, Infant, Infant, Newborn, Malaria, Falciparum (epidemiology), Malaria, Falciparum (parasitology), Male, Membrane Transport Proteins (genetics), Mutant Proteins (genetics), Plasmodium falciparum (genetics), Plasmodium falciparum (isolation & purification), Protozoan Proteins (genetics), Real-Time Polymerase Chain Reaction, Sequence Analysis, DNA.
- MESH :
- chemical , chemistry : DNA, Protozoan.
- chemical , genetics : DNA, Protozoan, Membrane Transport Proteins, Mutant Proteins, Protozoan Proteins.
- chemical , therapeutic use : Antimalarials, Chloroquine.
- geographic , epidemiology : Democratic Republic of the Congo.
- epidemiology : Malaria, Falciparum.
- genetics : Plasmodium falciparum.
- isolation & purification : Plasmodium falciparum.
- parasitology : Malaria, Falciparum.
- Child, Preschool, Drug Resistance, Female, Gene Frequency, Haplotypes, Humans, Infant, Infant, Newborn, Male, Real-Time Polymerase Chain Reaction, Sequence Analysis, DNA.
Abstract
In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype. This haplotype was first identified in Southeast Asia and South America but was recently reported in two African countries neighbouring DRC. These facts raised two questions: the first about the evolution of CQ resistance (CQR) in DRC and the second about the presence of the SVMNT haplotype, which would compromise the use of AQ as a partner drug for ACT.
DOI: 10.1186/1475-2875-12-459
PubMed: 24359280
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000309
- to stream PubMed, to step Curation: 000309
- to stream PubMed, to step Checkpoint: 000336
- to stream Ncbi, to step Merge: 000232
- to stream Ncbi, to step Curation: 000232
- to stream Ncbi, to step Checkpoint: 000232
- to stream Main, to step Merge: 001125
- to stream Main, to step Curation: 001124
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.</title><author><name sortKey="Mvumbi, Dieudonne Makaba" sort="Mvumbi, Dieudonne Makaba" uniqKey="Mvumbi D" first="Dieudonné Makaba" last="Mvumbi">Dieudonné Makaba Mvumbi</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry and Molecular Biology Unit, Department of Basic Sciences, School of Medicine, University of Kinshasa, BP 190 KIN XI, Kinshasa, DR Congo. didimvumbi@gmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country></affiliation></author><author><name sortKey="Boreux, Raphael" sort="Boreux, Raphael" uniqKey="Boreux R" first="Raphael" last="Boreux">Raphael Boreux</name></author><author><name sortKey="Sacheli, Rosalie" sort="Sacheli, Rosalie" uniqKey="Sacheli R" first="Rosalie" last="Sacheli">Rosalie Sacheli</name></author><author><name sortKey="Lelo, Mvumbi" sort="Lelo, Mvumbi" uniqKey="Lelo M" first="Mvumbi" last="Lelo">Mvumbi Lelo</name></author><author><name sortKey="Lengu, Bobanga" sort="Lengu, Bobanga" uniqKey="Lengu B" first="Bobanga" last="Lengu">Bobanga Lengu</name></author><author><name sortKey="Nani Tuma, Situakibanza" sort="Nani Tuma, Situakibanza" uniqKey="Nani Tuma S" first="Situakibanza" last="Nani-Tuma">Situakibanza Nani-Tuma</name></author><author><name sortKey="Melin, Pierrette" sort="Melin, Pierrette" uniqKey="Melin P" first="Pierrette" last="Melin">Pierrette Melin</name></author><author><name sortKey="Ntumba, Kayembe" sort="Ntumba, Kayembe" uniqKey="Ntumba K" first="Kayembe" last="Ntumba">Kayembe Ntumba</name></author><author><name sortKey="Lunganza, Kalala" sort="Lunganza, Kalala" uniqKey="Lunganza K" first="Kalala" last="Lunganza">Kalala Lunganza</name></author><author><name sortKey="Demol, Patrick" sort="Demol, Patrick" uniqKey="Demol P" first="Patrick" last="Demol">Patrick Demol</name></author><author><name sortKey="Hayette, Marie Pierre" sort="Hayette, Marie Pierre" uniqKey="Hayette M" first="Marie-Pierre" last="Hayette">Marie-Pierre Hayette</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24359280</idno><idno type="pmid">24359280</idno><idno type="doi">10.1186/1475-2875-12-459</idno><idno type="wicri:Area/PubMed/Corpus">000309</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000309</idno><idno type="wicri:Area/PubMed/Curation">000309</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000309</idno><idno type="wicri:Area/PubMed/Checkpoint">000336</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000336</idno><idno type="wicri:Area/Ncbi/Merge">000232</idno><idno type="wicri:Area/Ncbi/Curation">000232</idno><idno type="wicri:Area/Ncbi/Checkpoint">000232</idno><idno type="wicri:Area/Main/Merge">001125</idno><idno type="wicri:Area/Main/Curation">001124</idno><idno type="wicri:Area/Main/Exploration">001124</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.</title><author><name sortKey="Mvumbi, Dieudonne Makaba" sort="Mvumbi, Dieudonne Makaba" uniqKey="Mvumbi D" first="Dieudonné Makaba" last="Mvumbi">Dieudonné Makaba Mvumbi</name><affiliation wicri:level="1"><nlm:affiliation>Biochemistry and Molecular Biology Unit, Department of Basic Sciences, School of Medicine, University of Kinshasa, BP 190 KIN XI, Kinshasa, DR Congo. didimvumbi@gmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country></affiliation></author><author><name sortKey="Boreux, Raphael" sort="Boreux, Raphael" uniqKey="Boreux R" first="Raphael" last="Boreux">Raphael Boreux</name></author><author><name sortKey="Sacheli, Rosalie" sort="Sacheli, Rosalie" uniqKey="Sacheli R" first="Rosalie" last="Sacheli">Rosalie Sacheli</name></author><author><name sortKey="Lelo, Mvumbi" sort="Lelo, Mvumbi" uniqKey="Lelo M" first="Mvumbi" last="Lelo">Mvumbi Lelo</name></author><author><name sortKey="Lengu, Bobanga" sort="Lengu, Bobanga" uniqKey="Lengu B" first="Bobanga" last="Lengu">Bobanga Lengu</name></author><author><name sortKey="Nani Tuma, Situakibanza" sort="Nani Tuma, Situakibanza" uniqKey="Nani Tuma S" first="Situakibanza" last="Nani-Tuma">Situakibanza Nani-Tuma</name></author><author><name sortKey="Melin, Pierrette" sort="Melin, Pierrette" uniqKey="Melin P" first="Pierrette" last="Melin">Pierrette Melin</name></author><author><name sortKey="Ntumba, Kayembe" sort="Ntumba, Kayembe" uniqKey="Ntumba K" first="Kayembe" last="Ntumba">Kayembe Ntumba</name></author><author><name sortKey="Lunganza, Kalala" sort="Lunganza, Kalala" uniqKey="Lunganza K" first="Kalala" last="Lunganza">Kalala Lunganza</name></author><author><name sortKey="Demol, Patrick" sort="Demol, Patrick" uniqKey="Demol P" first="Patrick" last="Demol">Patrick Demol</name></author><author><name sortKey="Hayette, Marie Pierre" sort="Hayette, Marie Pierre" uniqKey="Hayette M" first="Marie-Pierre" last="Hayette">Marie-Pierre Hayette</name></author></analytic><series><title level="j">Malaria journal</title><idno type="eISSN">1475-2875</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (therapeutic use)</term><term>Child, Preschool</term><term>Chloroquine (therapeutic use)</term><term>DNA, Protozoan (chemistry)</term><term>DNA, Protozoan (genetics)</term><term>Democratic Republic of the Congo (epidemiology)</term><term>Drug Resistance</term><term>Female</term><term>Gene Frequency</term><term>Haplotypes</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Malaria, Falciparum (epidemiology)</term><term>Malaria, Falciparum (parasitology)</term><term>Male</term><term>Membrane Transport Proteins (genetics)</term><term>Mutant Proteins (genetics)</term><term>Plasmodium falciparum (genetics)</term><term>Plasmodium falciparum (isolation & purification)</term><term>Protozoan Proteins (genetics)</term><term>Real-Time Polymerase Chain Reaction</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN des protozoaires ()</term><term>ADN des protozoaires (génétique)</term><term>Analyse de séquence d'ADN</term><term>Antipaludiques (usage thérapeutique)</term><term>Chloroquine (usage thérapeutique)</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Haplotypes</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Paludisme à Plasmodium falciparum (parasitologie)</term><term>Paludisme à Plasmodium falciparum (épidémiologie)</term><term>Plasmodium falciparum (génétique)</term><term>Plasmodium falciparum (isolement et purification)</term><term>Protéines de protozoaire (génétique)</term><term>Protéines de transport membranaire (génétique)</term><term>Protéines mutantes (génétique)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>République démocratique du Congo (épidémiologie)</term><term>Résistance aux substances</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA, Protozoan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Protozoan</term><term>Membrane Transport Proteins</term><term>Mutant Proteins</term><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Democratic Republic of the Congo</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Malaria, Falciparum</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN des protozoaires</term><term>Plasmodium falciparum</term><term>Protéines de protozoaire</term><term>Protéines de transport membranaire</term><term>Protéines mutantes</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria, Falciparum</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Paludisme à Plasmodium falciparum</term><term>République démocratique du Congo</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term><term>Drug Resistance</term><term>Female</term><term>Gene Frequency</term><term>Haplotypes</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Real-Time Polymerase Chain Reaction</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN des protozoaires</term><term>Analyse de séquence d'ADN</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Fréquence d'allèle</term><term>Haplotypes</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Résistance aux substances</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype. This haplotype was first identified in Southeast Asia and South America but was recently reported in two African countries neighbouring DRC. These facts raised two questions: the first about the evolution of CQ resistance (CQR) in DRC and the second about the presence of the SVMNT haplotype, which would compromise the use of AQ as a partner drug for ACT.</div></front></TEI><affiliations><list><country><li>Oman</li></country></list><tree><noCountry><name sortKey="Boreux, Raphael" sort="Boreux, Raphael" uniqKey="Boreux R" first="Raphael" last="Boreux">Raphael Boreux</name><name sortKey="Demol, Patrick" sort="Demol, Patrick" uniqKey="Demol P" first="Patrick" last="Demol">Patrick Demol</name><name sortKey="Hayette, Marie Pierre" sort="Hayette, Marie Pierre" uniqKey="Hayette M" first="Marie-Pierre" last="Hayette">Marie-Pierre Hayette</name><name sortKey="Lelo, Mvumbi" sort="Lelo, Mvumbi" uniqKey="Lelo M" first="Mvumbi" last="Lelo">Mvumbi Lelo</name><name sortKey="Lengu, Bobanga" sort="Lengu, Bobanga" uniqKey="Lengu B" first="Bobanga" last="Lengu">Bobanga Lengu</name><name sortKey="Lunganza, Kalala" sort="Lunganza, Kalala" uniqKey="Lunganza K" first="Kalala" last="Lunganza">Kalala Lunganza</name><name sortKey="Melin, Pierrette" sort="Melin, Pierrette" uniqKey="Melin P" first="Pierrette" last="Melin">Pierrette Melin</name><name sortKey="Nani Tuma, Situakibanza" sort="Nani Tuma, Situakibanza" uniqKey="Nani Tuma S" first="Situakibanza" last="Nani-Tuma">Situakibanza Nani-Tuma</name><name sortKey="Ntumba, Kayembe" sort="Ntumba, Kayembe" uniqKey="Ntumba K" first="Kayembe" last="Ntumba">Kayembe Ntumba</name><name sortKey="Sacheli, Rosalie" sort="Sacheli, Rosalie" uniqKey="Sacheli R" first="Rosalie" last="Sacheli">Rosalie Sacheli</name></noCountry><country name="Oman"><noRegion><name sortKey="Mvumbi, Dieudonne Makaba" sort="Mvumbi, Dieudonne Makaba" uniqKey="Mvumbi D" first="Dieudonné Makaba" last="Mvumbi">Dieudonné Makaba Mvumbi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001124 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001124 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24359280
|texte= Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24359280" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |